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Buy Zudena 100mg tablet Generic drug of Sildenafil Citrate / Duloxetine online at a reasonable price from the most trusted website to cure erectile dysfunction. Get all information regarding this medicine like the review, use, Precautions, dosage (Missed/Over), Composition, Substitutes, side effect, manufacture by Sunrise Remedies, how it works, how long does last and many more. You can also get fast delivery in the UK, USA, Australia from medipharmas.shop
1. Buy Zudena 100mg Online
Zudena Udenafil is a restorative specialist speculated to enhance erectile capability endpoints through collaboration with the phosphodiesterase compose five (PDE5) compound.
Buy Udenafil Online adequacy and averageness are assessed in an exceedingly few investigations, and later and continuing with have shown Udenafil’s guarantee in both dosing regimens. Udenafil as associate on-request or once-day by day measure is powerful and honest, but additional examinations area unit needed in patients of various ethnicities and with comorbid conditions, parenthetically, diabetes, cardiovascular disease, and kind prostate dysplasia. medipharmas.shop
2. What is Zudena 100mg Tablet?
Buy Zudena Udenafil is a new phosphodiesterase type 5 (PDE5) inhibitor used to treat erectile dysfunction (ED). It has been approved in South Korea and will be marketed under the brand name Zudena. medipharmas.shop
3. How To Take Zudena 100mg Tablet?
4. Mechanism Action Of Zudena 100mg?
Zudena Udenafila 100mg inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for the degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by vardenafil enhances erectile function by increasing the amount of cGMP. medipharmas.shop
5. Instruction for Zudena 100mg
Do not take Udenafil if you are also using a nitrate drug for chest pain or heart problems. This includes nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate. Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite (“poppers”). Taking Udenafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure. medipharmas.shop
6. Drug interaction of Zudena 100mg
Consult your doctor before taking Udenafil. Tell your doctor about all your current medicines and any you start or stop using, especially:
- Inhibitors of cytochrome P450 isoenzyme CYP3A4 (ketoconazole, itraconazole, ritonavir, indinavir, cimetidine, erythromycin, grapefruit juice) may enhance the action of Udenafil.
- Ketoconazole (400 mg) increases the bioavailability and Cmax of Udenafil (100 mg) almost 2-fold (212%) and 0.8-fold (85%), respectively.
- Ritonavir and indinavir substantially increase the effects of Udenafil.
- Dexamethasone, rifampin, and anticonvulsants drugs (carbamazepine, phenytoin, and phenobarbital) may accelerate the metabolism of Udenafil, so joint application with the above medications weakens the effect of Udenafil.
- The joint application of Udenafil (30 mg/kg orally) and nitroglycerin (2.5 mg/kg once, w / w) did not reveal any effect on the pharmacokinetics of Udenafil in experimental studies, but the simultaneous use of nitroglycerin and of Udenafil is not recommended because of possible reduce blood pressure.
- Udenafil and drugs from the group of alpha-blockers are vasodilators, therefore, the joint admission should be appointed at the minimum doses. medipharmas.shop
7. Zudena 100 mg Side Effects
- dry mouth,
- abdominal discomfort
- difficulty sleeping.
8. Warning of Zudena 100mg tablet
Sexual movement may be a potential hazard for patients with vas illness, thus treatment of erectile brokenness, together with utilizing of Udenafil, ought not to hold for men with a coronary health problem, within which sexual activity is not prompt.
Patients with a deterrent of blood outpouring from the heart ventricle (aortic stenosis) can be additional touchy to the activity of vasodilators, together with inhibitors of PDE. In spite of the absence of clinical trials of instances of delayed erection (longer than four hours) and pathology (agonizing erections enduring in more than half-dozen h), such marvels area unit not possible to miss to the current category of medicines.
just in case of AN erection enduring over four hours (paying very little relation to torment), patients need to promptly hunt for restorative facilitate. while not convenient treatment of pathology will prompt irreversible damage to the animal tissue and erectile capability. medipharmas.shop
9. Precaution of Zudena 100mg tablet
Sexual activity is a potential risk for patients with cardiovascular disease, so treatment of erectile dysfunction, including using of Udenafil, should not hold for men with heart disease, in which sexual activity is not recommended.
Patients with obstruction of blood outflow from the left ventricle (aortic stenosis) may be more sensitive to the action of vasodilators, including inhibitors of PDE. Despite the lack of clinical trials of cases of a prolonged erection (longer than 4 hours) and priapism (painful erections lasting more than 6 h), such phenomena are peculiar to this class of drugs. In the event of an erection lasting more than 4 hours (regardless of pain), patients should immediately seek medical help. The absence of timely treatment of priapism can lead to irreversible damage to the erectile tissue and erectile function.
List of those who must take Zudena with extra caution:
Patients with uncontrolled hypertension,
Patients with hereditary degenerative diseases of the retina (including retinitis pigmentosa, proliferative diabetic retinopathy);
Patients who have undergone over the last 6 months of stroke, myocardial infarction, or coronary artery bypass grafting;
Patients with severe hepatic or renal impairment; the presence of congenital long QT syndrome, or an increase in the QT interval as a result of taking the drugs; predisposition to priapism;
Patients with anatomical deformation of the penis; the presence of penile implant; sexual activity in patients with diseases of the cardiovascular system such as unstable angina or angina occurring during sexual intercourse, chronic heart failure (II-IV functional class NYHA classification), which developed during the last 6 months, uncontrolled heart rhythm disorders hypotension. medipharmas.shop
10. Zudena 100mg Dosage
The recommended dose is 100 mg, taken 30 minutes before anticipated sexual activity
If Zudena is used as needed, you are not likely to be on a dosing schedule. The maximum recommended frequency of application – 1 time per day.
11. Safety information about Zudena 100mg
We provide only general information about medications that does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim the reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special, or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment. medipharmas.shop
12. Uses of Zudena 100mg
Treatment of erection disorders, characterized by the inability to achieve or maintain penile erection sufficient for satisfactory sexual intercourse.
Zudena has the following active ingredient: Udenafil. Zudena (Udenafil) is a therapeutic agent hypothesized to improve erectile dysfunction through interaction with the phosphodiesterase type 5 (PDE5) enzyme. medipharmas.shop
13. Storage of Zudena 100mg
Store Zudena in a dry, dark place at a temperature no higher than 86° F (30° C). Do not store drugs in the bathroom. Keep all drugs out of the reach of children and pets.